Curebase alternatives for teams that want the participant experience under their own brand

Curebase has become a structured eClinical platform that runs a trial from study startup to database lock. If what you need most is a participant app that carries your organisation's name, native wearable data, and engagement that holds up over years rather than one study, that's where WeGuide fits. Whitelabel iOS and Android apps, eConsent, eCOA, and a no code Program Builder, on a managed platform that connects to the EDC you already run.

Organise a demo See the full comparison

No pressure, no hard sell. A 30 minute walkthrough with a research colleague who's built platforms like yours.

Where WeGuide differs

Whitelabel participant mobile apps
Native wearable and sensor data
A participant layer that works with your EDC

Used by leading research and medical institutes.

Why research teams look for a Curebase alternative

The short version

Curebase has changed shape. In 2022 it described itself as an end to end clinical trial company with a network of virtual and hybrid site staff. Today it sells one AI eClinical platform covering recruitment, eConsent, eCOA/ePRO, engagement and EDC, plus a free product for research sites called Sitebase. For a lean biotech or medtech team that wants one vendor and one data model from first patient to database lock, that's a strong proposition.

See the full comparison

Why teams look elsewhere

The fit gap shows up when the study isn't really about the database. Some teams need the participant to experience the study as their own institution's programme, with an app in the store under their name, not a vendor's. Some protocols depend on continuous data from Garmin, Apple Health, Health Connect or Fitbit Air rather than questionnaires alone. Some programmes are registries and cohorts that run for years and outlive any single database lock. And many academic and investigator led teams already have an EDC, often REDCap, that they're not ready to replace just to get a better participant experience.

We built WeGuide for that side of the study: the participant facing layer. eScreening, eConsent, eCOA, engagement, telehealth and wearable data in a whitelabel app, configured by your own team through a no code Program Builder, and connected to your data capture system through our Integration Engine. If what you need is a single platform that owns EDC end to end, Curebase may well be the better choice, and we'll say so on the first call.

In practice, the decision usually comes down to one question: what is the centre of gravity of your study? If it's the clinical database, with data managers, source data verification and a lock date driving every decision, a unified eClinical platform like Curebase is built around that. If it's the participant, with recruitment, consent, adherence and retention over months or years driving every decision, you want a platform built around the participant's phone. WeGuide is built for the second group, and it works best when there's already a data capture system the team is happy with.

Key differences between WeGuide and Curebase

For teams whose study lives or dies on the participant experience, here's what changes when you move to WeGuide.

Whitelabel participant mobile apps

WeGuide ships native iOS and Android apps, and each study can be published under your organisation's own App Store account and name, or run in the existing WeGuide app. Curebase's product pages describe a participant experience that runs across iOS, Android, tablet and desktop, but they don't describe a whitelabel app published under the sponsor's brand. For registries, cohorts and investigator led studies, the name on the participant's home screen is part of why people stay.

Native wearable and sensor data

Garmin, Apple Health, Health Connect and Fitbit Air integrations are built into WeGuide, so passive data arrives alongside eCOA responses without a separate device vendor. On supported Garmin models, WeGuide can also collect raw accelerometer and gyroscope data at 25 Hz through the Garmin Health SDK. Curebase's current product pages focus on eCOA, eConsent, EDC and AI, and don't describe native wearable integrations. If sensor data is central to your protocol, that difference matters before you sign, because adding a device vendor later means another contract, another validation and another app for participants.

A participant layer that works with your EDC

Curebase is built to be the system of record, including its own EDC. WeGuide is built to be the participant layer and to connect outwards: two way REDCap sync, Salesforce, HL7 and FHIR, plus a REST API and webhooks. If your institution already has a data capture system it trusts, you can keep it and still give participants a modern app.

Compare

Full comparison: WeGuide vs Curebase

REDCap

Feature

Request a Demo

Primary use case

Participant engagement platform with eScreening, eConsent, eCOA, telehealth, wearables and registries

Unified eClinical platform from study startup to database lock (recruitment, eConsent, eCOA/ePRO, engagement, EDC)

Target customer

Academic research, investigator led studies, registries, CROs, mid market sponsors, digital health programmes

Biotech, medtech, pharma and CROs, plus research sites through Sitebase

Delivery model

Technology platform configured with your team, named delivery contact

Technology platform, earlier positioning included virtual and hybrid site staff

Whitelabel mobile app

Yes, native iOS and Android apps under your own App Store account and name, or the existing WeGuide app

Not described on product pages, participant access across iOS, Android, tablet and desktop

eCOA and ePRO

Native, with a library of validated instruments, on participants' own phones or provisioned devices

Native, with a prebuilt instrument library, provisioned or BYOD, offline support

eConsent

Built in, with version control, reconsent workflows and audit trail

Built in, with version control, reconsent support, multimedia content, 40+ languages

EDC

Not an EDC, two way sync with REDCap and other systems through the Integration Engine

Native EDC with queries, SDV, freeze and lock, CDISC compliant export

Native wearable integration

Garmin, Apple Health, Health Connect and Fitbit Air, plus raw accelerometer and gyroscope at 25 Hz on supported Garmin models

Not described on current product pages

Engagement

Push notifications, in app messaging, scheduling, patient education content, gamification

SMS, email and in app reminders, smart scheduling, built in stipends

Telehealth

Built in televisits

Telemedicine integration with in app appointment booking

AI features

Not a headline feature

Hope voice agent, eCOA Vigilance drop off monitoring, AI form builder

Site tools

Not offered, CTMS and site binders stay in your existing systems and connect through integration

Sitebase: free CTMS, eISF, eSource and eConsent for research sites

Registries and longitudinal cohorts

Core use case (FSHD Global registry, GenV birth cohort)

Not presented as a core use case

No code configuration

Program Builder and Medical Form Builder with conditional logic, configured by your team

Drag and drop eConsent builder and AI form builder

Multilingual studies

Built in translation management (used on the INHERIT study)

Global language support built in, automated translations on engagement channels

Security and compliance

ISO 27001:2022, HIPAA (BAA available), GDPR, FDA 21 CFR Part 11, TGA registered Class I medical device software

SOC 2 Type II, GDPR, 21 CFR Part 11 audit trails and signatures, CDISC Gold Member

Pricing

Project based, quote on request, includes hosting, support and modules

Not published, quote on request. Sitebase is free for sites

REDCap

Top alternatives to Curebase in 2026

Here's the shortlist of platforms most teams evaluate alongside Curebase. Each one has a different sweet spot, so start with what your protocol actually needs: a full eClinical stack, an enterprise DCT platform, or a participant layer that sits on top of the data capture you already have.

Alternative #1

Where WeGuide goes further

For teams that want the participant side of a study in one platform, here's what changes when you move to WeGuide.

Whitelabel apps under your brand

Native wearable data

Keep the EDC you already trust

Engagement built for the long haul

Registries and cohorts, not just trials

Configured by your own team

Security your IT team can sign off

Pricing scoped to your study

Built for regulated research

Every WeGuide study runs on our managed infrastructure. Your IT team doesn't patch servers, manage backups, or run disaster recovery drills.

TGA Registered

Registered Class I medical device software with the Therapeutic Goods Administration.

ISO 27001

Certified information security management covering access, audit, and incident response.

Data Hosted in Australia

Participant data is hosted in Australian data centres with sovereign data controls.

GDPR Compliant

GDPR, HIPAA, and 21 CFR Part 11 ready for multi-country and US-based studies.

Biometric Security

Participant access protected by PIN code and biometric authentication on device.

256-bit AES Encryption

All data encrypted at rest and in transit with automated backups and disaster recovery.

Where Curebase excels

One system from startup to database lock. Recruitment, eConsent, eCOA/ePRO, engagement and EDC share one data model. For a lean biotech or medtech team that doesn't want to integrate four vendors, that's a genuine operational advantage, and it's something WeGuide, as a participant layer, doesn't try to replace.

A real EDC with data management workflows. Query management, targeted source data verification, freeze and lock, validated electronic signatures and CDISC compliant export are built in. Curebase is a CDISC Gold Member, which tells you where its data team's priorities sit.

Sitebase is free for research sites. CTMS, eISF, eSource and eConsent at no cost to sites, with no per user or per participant fees. Sites that already use Sitebase will find a Curebase sponsored study familiar, and that helps with site activation.

AI that is part of the workflow. The Hope voice agent handles calls, scheduling and reminders, and eCOA Vigilance flags participants at risk of dropping out so sites can reach out early. If your operating model leans on automation to cover thin site staff, that's useful.

Real decentralised trial history. Before the platform repositioning, Curebase ran studies as a virtual and hybrid trial company, including a partnership for at home sample collection in US decentralised trials. That operational history informs a product built by people who have run remote studies, not only designed software for them.

Broad eConsent language coverage. Curebase lists support for more than 40 languages in eConsent, with video, images and comprehension quizzes. For multinational studies where consent is the first hurdle, that's a practical strength.

If your study needs one vendor to own EDC, eCOA and eConsent through to database lock, Curebase is a defensible choice. We'd rather tell you that than sell you a participant platform when what you need is a data platform.

WeGuide alongside Curebase

‍

In most cases teams choose one. Curebase is designed to be the single system for the sponsor and the site, and running a second participant facing app on the same study usually adds work rather than removing it. Where it can make sense is across a portfolio: a sponsor running interventional trials on Curebase while an affiliated registry, cohort or long term follow up programme runs on WeGuide, with data exchanged through our REST API and webhooks. We don't have a prebuilt Curebase connector, so we'd scope any data flow on the discovery call.

The other common pattern is sequencing rather than running in parallel. A sponsor finishes an interventional study on Curebase, then moves consenting participants into a long term follow up or registry on WeGuide, under the sponsor's own brand, with the consent and data sharing arrangements agreed up front. That keeps each platform doing the job it was built for.

How the switch works

For teams moving their participant experience from Curebase to WeGuide, or starting a registry or follow up programme on WeGuide, here's how onboarding typically plays out.

Discovery Call

A 30 minute conversation with one of our research delivery team. We look at your protocol, how you use Curebase today, and which parts of the study are really about the participant rather than the database. If keeping Curebase for EDC is the better answer for your study, we'll say that. No sales pitch.

Study Configuration

Our team works alongside yours to configure the study in WeGuide: consent flows, eCOA schedules, engagement content and wearable connections. If you're keeping an EDC, we configure the Integration Engine at this stage. Typical timeline: two to four weeks.

Participant Onboarding

The whitelabel app goes live, under your own App Store account and name or in the existing WeGuide app. Your coordinators invite participants, consent flows, reminders and education content are ready from day one, and wearable connections start syncing as soon as a participant authorises them.

Ongoing Support

You get a named research delivery contact, not a ticketing queue. We stay involved for the life of the study.

Case studies: research teams that put the participant experience first

BRACE Trial (Murdoch Children's Research Institute)

Murdoch Children's Research Institute's BRACE trial was an international randomised trial testing the BCG vaccine in healthcare workers during COVID-19. It ran across several countries with thousands of participants. It was a hybrid trial: vaccination and blood collection happened in person, and WeGuide supported the participant facing side of the study. It's a good example of the model most real studies use: the clinic does what only a clinic can, and the participant's phone does the rest.

GenV (Generation Victoria)

Generation Victoria (GenV) is a whole of state longitudinal birth cohort in Victoria, Australia, following roughly 124,000 people (about 50,000 children and 74,000 parents). A cohort like that isn't a study with a database lock date. It needs a participant relationship that lasts for years, and engagement at that scale runs on push notifications, scheduling and education content rather than coordinator phone calls.

FSHD Global

FSHD Global runs a longitudinal patient registry for facioscapulohumeral muscular dystrophy on WeGuide, combining patient reported outcomes with wearable integration. It's the kind of programme that sits outside a trial focused eClinical platform: open ended, participant led, and built around a community rather than a protocol. Participants report outcomes from their own phones, and wearable data adds a continuous picture between those reports.

Helping researchers transform ideas into discoveries.

Hear what our clients have to say!

"GenV trusted WeGuide to run a multi-year population health study with roughly 124,000 Victorians, about 50,000 children and 74,000 parents. Longitudinal engagement at this scale requires push notifications, multi-modal data capture, and a whitelabel app that families will keep on their phones for years.""

Susan Clifford

Senior Research Officer

“The main benefit of WeGuide is its convenience. I can’t imagine how we would follow thousands of participants and collect their data without WeGuide!”

Kaya Gardiner

Trial Project Manager

"WeGuide has transformed how we manage our patient registry. The ease of digital screening and obtaining eConsent has significantly improved our workflow."

Emma Weatherley

Managing Director

"The WeGuide trial offers staff a practical tool for recording daily COVID-19 symptoms and temperatures. For those in high-risk areas, daily reminders and alerts provide peace of mind and reassurance about their health."

Kate Cranwell

Manager

"It’s obvious that WeGuide is committed to develop technology that benefits people in the community. WeGuide has been a great partner in achieving this goal within Western Health."

Paul Eleftheriou

Chief Medical Officer

Questions

Straight answers on how WeGuide compares to Curebase, what switching looks like, and when Curebase is the right call.

What is Curebase?

Curebase is an AI eClinical platform founded in 2017 that combines recruitment, eConsent, eCOA/ePRO, participant engagement and EDC in one system for biotech, medtech, pharma and CROs. It also offers Sitebase, a free CTMS, eISF and eSource product for research sites. Earlier in its history it positioned itself as an end to end decentralised trial company with virtual and hybrid site staff.

What are the best Curebase alternatives?

It depends on what you need from the platform. WeGuide is the fit if the participant experience, whitelabel apps, wearables and long term engagement matter most. Jeeva Trials is the closest like for like option if you want EDC and eCOA from one vendor. Medable and Medidata suit enterprise pharma programmes, and ObvioHealth suits sponsors who want a participant app and clinical trial services together.

Does WeGuide replace Curebase's EDC?

No. WeGuide isn't an EDC. It's the participant facing layer: eScreening, eConsent, eCOA, engagement, telehealth and wearable data. Teams typically keep their EDC and connect it through the Integration Engine, which supports two way REDCap sync, HL7 and FHIR, and a REST API with webhooks. If you need one vendor to own EDC end to end, Curebase or Jeeva Trials is the more direct fit.

Does Curebase support wearables?

Curebase's current product pages focus on eCOA, eConsent, EDC, engagement and AI, and don't describe native wearable integrations, although an older Curebase marketplace listing mentions centralised access to wearable data. Ask Curebase directly about your specific devices. WeGuide integrates natively with Garmin, Apple Health, Health Connect and Fitbit Air, and collects raw accelerometer and gyroscope data at 25 Hz on supported Garmin models.

How is WeGuide priced compared with Curebase?

Neither company publishes a price list for sponsors. WeGuide is priced per project, quoted on request, with hosting, support and modules included, so there's no separate line for the whitelabel app or wearable integrations. Curebase quotes on request, and its Sitebase product is free for research sites, funded by sponsors running studies on Curebase.

How long does it take to move a study to WeGuide?

Configuration alongside your team typically takes two to four weeks after a discovery call. For a study already running on Curebase, we'd plan the participant transition and any data export with you before setting a date, and for many teams the cleaner path is to start new studies, registries or follow up programmes on WeGuide.

More comparisons